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Updated: Mar 3, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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α-Trifluoromethyl Substituted α-Hydroxyhydrazides as Dianionic Ligands Enable Cu-Catalyzed Aryl Amination With Higher

Junying Ye1, Bin Guo1, Rongxing Zhang1

  • 1Shenzhen Key Laboratory of Cross-Coupling Reactions & Department of Chemistry, Southern University of Science and Technology (SUSTech), Shenzhen, China.

Angewandte Chemie (International Ed. in English)
|March 2, 2026
PubMed
Abstract

Keywords:
(hetero)aryl halidesaryl aminationcopper catalystcoupling reactionα‐trifluoromethyl‐substituted α‐hydroxy‐hydrazide ligands

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