Related Experiment Video

Updated: Mar 3, 2026

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.6K

Correlation of Pulse Pressure Index and High-sensitivity C-reactive Protein as Predictors of Diastolic Dysfunction in

Taruguvandla Sandhya Rani1, Ravi Teja Nalabothula, Subramaniyan Kumarasamy

  • 1Department of General Medicine, SRM Medical College Hospital and Research Centre Kattankulathur, Chengalpattu, Tamil Nadu, India.

The Nigerian Postgraduate Medical Journal
|March 2, 2026
PubMed

Insights

High-sensitivity C-reactive protein (hs-CRP) strongly indicates inflammation-related diastolic dysfunction in hypertension. Pulse pressure index (PPI) reflects vascular stiffness, aiding early detection and intervention in hypertensive patients.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Hypertension Research

Background:

  • Pulse pressure index (PPI) and high-sensitivity C-reactive protein (hs-CRP) are potential biomarkers for vascular compliance and inflammation.
  • These markers may predict diastolic dysfunction in individuals with hypertension.

Purpose of the Study:

  • To investigate the association between PPI and hs-CRP levels and diastolic dysfunction.
  • To evaluate these markers in newly diagnosed essential hypertensive patients.

Main Methods:

  • Prospective observational study of 82 newly diagnosed hypertensive patients (>40 years).
  • Baseline measurement of PPI and hs-CRP, with echocardiography for diastolic dysfunction (DD) assessment.
  • Standard antihypertensive therapy and follow-up at 3 and 6 months.

Main Results:

  • Diastolic dysfunction was present in 74.4% of patients at baseline.
  • hs-CRP showed a strong positive association with diastolic dysfunction (β = 0.885, P = 0.025).
  • PPI had a moderate correlation (β = 0.475, P = 0.035); antihypertensive therapy improved diastolic function (P = 0.032).

Conclusions:

  • hs-CRP is a significant indicator of inflammation-driven diastolic dysfunction.
  • PPI serves as a marker for vascular stiffness in hypertensive patients.
  • Early identification using hs-CRP and PPI can improve clinical assessment and guide interventions.
Abstract

Keywords:
Diastolic dysfunctionechocardiographyhigh-sensitivity C-reactive proteinhypertensionpulse pressure index

More Related Videos

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

18.7K
Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

11.6K

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
658
Blood Pressure01:24

Blood Pressure

The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...
10.6K
Pulse01:16

Pulse

When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
The pulse serves as a clinical...
2.4K
Measurement of Blood Pressure01:17

Measurement of Blood Pressure

Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
3.6K
Sites for measuring blood pressure01:21

Sites for measuring blood pressure

Blood pressure measurement is a fundamental clinical procedure, providing crucial data for assessing cardiovascular health. Among the various sites for this measurement, the brachial and popliteal arteries are predominantly utilized due to their accessibility and the reliability of their readings. This lesson delves into the anatomical significance, methodology, and considerations of measuring blood pressure at these locations.
The Brachial Artery: Primary Site for Blood Pressure Measurement
3.9K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
686