Related Experiment Video
Updated: Mar 3, 2026

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
Published on: December 3, 2019
The HIV reservoir landscape in elite controllers
Cristina Moral-Turón1, María Antequera-Martínez, Ezequiel Ruiz-Mateos
1Institute of Biomedicine of Seville, IBiS/Virgen Del Rocío University Hospital/CSIC/University of Seville, Clinical Unit of Infectious Diseases, Microbiology and Parasitology, Seville, Spain.
Purpose Of Review:
In this review, we intend to define the main characteristics of the elite controller reservoir, exploring into its heterogeneity, which goes hand in hand with the different progression phenotypes within elite controllers.
Recent Findings:
Show that the viral reservoir measured by high-resolution techniques in elite controllers is heterogeneous, exhibiting distinct characteristics in elite controllers who ultimately lose control compared to those with persistent viral remission. Among the latter, we find exceptional individuals with a reservoir consistent with a phenomenon of "block and lock," and even with a potential sterilizing cure.
Summary:
The HIV-1 reservoir in elite controllers is heterogeneous; discriminating the distinct characteristics of reservoir profiles in elite controllers can provide important clues about how to achieve an HIV cure.
More Related Videos
07:21Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
Published on: June 23, 2019
10:18Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
Published on: October 16, 2018
Related Concept Videos
Retrovirus Life Cycles
Retroviruses
Size and Structure of Viral Genomes