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Updated: Mar 3, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Head and Neck Cancers and Health Equity in the United States
Edward Christopher Dee1, Michael P Wu2, Nancy Y Lee1
1Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Abstract:
Persistent inequities in cancer care in the United States shape outcomes across the entire cancer continuum, and head and neck cancers offer a compelling lens through which to examine these structural drivers. In their population-based analysis, Tortolero and colleagues demonstrate that non-Hispanic Black and Hispanic patients with oral cavity cancer experience markedly higher odds of late-stage diagnosis, with neighborhood-level social vulnerability further magnifying these disparities. These findings reinforce that delayed diagnosis reflects not individual behaviors but broader determinants, including socioeconomic precarity, transportation barriers, limited health literacy, and fragmented access to timely evaluation. Evidence across head and neck and other cancers, such as laryngeal and prostate malignancies, underscores that racial differences in outcomes often attenuate when upstream factors and access to high-quality care are addressed. Emerging qualitative and health services research highlights additional barriers and potential structural interventions. Advancing equity in head and neck oncology will require pairing tumor-specific advances with policies that expand access, coordination, and continuity of care. See related article by Tortolero et al., p. 398.
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