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Transcriptomic Subtypes Are Associated with Clinical Outcomes for Patients with Lung Adenocarcinoma Who Have Never
Alexander A Azizi1,2,3,4, Tej Pandya1,2,5, Charles Swanton1,2,3
1Cancer Evolution and Genome Instability Laboratory, Francis Crick Institute, London, United Kingdom.
None:
Lung adenocarcinoma arising in individuals who have never smoked is understudied, represents a substantial global health burden, and is genomically distinct from smoking-associated disease. Zhao and colleagues have identified transcriptomic subtypes with prognostic value, including in stage I disease, supporting phenotypic state as an important determinant of outcome for lung adenocarcinoma in individuals who have never smoked. See related article by Zhao et al., p. 460.
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