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Related Experiment Video

Updated: Mar 3, 2026

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
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Isolated Infantile Onset High Myopia: A Case Series with Long-Term Follow-Up.

Gal Antman1,2, Miriam Ehrenberg2,3, Alon Tiosano1,2

  • 1Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel.

Current Eye Research
|March 2, 2026
PubMed
Summary

Isolated infantile onset high myopia (IIOHM) appears stable in the first decade with good visual outcomes. Monitoring for amblyopia and strabismus is crucial as refractive changes may increase later.

Keywords:
Isolated infantile onset high myopiahigh myopiainfantile onset high myopia

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Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Genetics

Background:

  • Isolated infantile onset high myopia (IIOHM) is a rare condition.
  • Understanding its natural progression is essential for management.

Purpose of the Study:

  • To describe the long-term natural course of IIOHM.
  • To evaluate refractive error progression and visual acuity in affected children.

Main Methods:

  • Retrospective review of patients under 5 years with bilateral spherical equivalent (SE) ≤ -5.0D.
  • Exclusion of cases with short follow-up, anisometropia, astigmatism, or associated systemic/ocular diseases.
  • Data collection on refractive error and visual acuity at presentation and follow-up.

Main Results:

  • Nineteen patients (38 eyes) were analyzed.
  • Myopia increased significantly from -8.4D to -9.5D (p=0.003) over follow-up.
  • A negative correlation was found between initial SE and progression (p=0.01).
  • Mean best-corrected visual acuity (BCVA) was 6/7.5; 47.4% had strabismus, but no severe complications arose.

Conclusions:

  • IIOHM demonstrates stability in the first decade with a generally good visual prognosis.
  • Close monitoring for amblyopia and strabismus is recommended.
  • Anticipate potential for significant refractive changes in the second decade.