A Case of Intermittent Fever a Decade After Renal Transplantation

Disseminated histoplasmosis is a potentially serious complication after organ transplantation; however, its occurrence is rare, even in endemic regions. Diagnosis can be challenging, particularly in patients with nonspecific symptoms such as intermittent fever or lethargy. We report the case of a man who presented with intermittent fever 10 years after kidney transplantation. His presentation initially raised suspicion for post-transplant lymphoproliferative disorder (PTLD) but was ultimately diagnosed as disseminated histoplasmosis following mediastinal lymph node biopsy and fungal tissue culture.