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Scaffold-based biomaterials in ovarian tissue engineering.

Chiara Di Berardino1, Liliana Liverani2,3, Aldo R Boccaccini2

  • 1Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo 64100 Teramo Italy cdiberardino@unite.it.

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Summary
This summary is machine-generated.

Biomaterials are crucial for artificial ovary development in fertility preservation. Hybrid strategies combining natural and synthetic materials show promise for restoring ovarian function, though challenges remain.

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Area of Science:

  • Reproductive Medicine
  • Biomaterials Science
  • Tissue Engineering

Background:

  • Conventional assisted reproductive technologies are insufficient for early follicle depletion.
  • Reproductive tissue engineering utilizes biomaterials for artificial ovary development.
  • Ovarian function restoration and fertility preservation are key goals.

Purpose of the Study:

  • To systematically review biomimetic scaffold strategies for ovarian tissue engineering.
  • To analyze material composition, structural design, biofunctionality, and translational relevance.
  • To identify promising biomaterial approaches for artificial ovary development.

Main Methods:

  • Systematic review following PRISMA 2020 guidelines.
  • Analysis of 137 studies on biomimetic scaffolds for ovarian tissue engineering.
  • Inclusion of studies on hydrogels, decellularized ECM, electrospun, and 3D-printed scaffolds.

Main Results:

  • Natural and ECM-based scaffolds offer biological cues but have limitations.
  • Synthetic scaffolds, like electrospun poly(ε-caprolactone), provide architectural control and scalability.
  • Both in vitro and in vivo studies across mammalian models were analyzed.

Conclusions:

  • Hybrid biomaterial strategies integrating biological cues and scaffold tunability are most promising.
  • Standardization and translational validation are critical challenges for artificial ovary development.
  • Biomaterials are essential for advancing fertility preservation and ovarian function restoration.