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Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

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Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
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An explainable deep learning framework for biosensing data interpretation in biomedical engineering and real-time

Zheng Yang1,2, Weihong Huang3,4, Heng Zhang5

  • 1The Chinese University of Hong Kong, Shenzhen, Guangdong, China.

Frontiers in Bioengineering and Biotechnology
|March 2, 2026
PubMed
Summary

This study introduces an explainable AI framework using the PhysioGraph Inference Network (PGIN) for interpretable health assessments from biosignals. It achieves high accuracy, offering trustworthy biomedical intelligence for clinical use.

Keywords:
PhysioGraph inference network (PGIN)adaptive health state inference mechanism (AHSIM)diagnostic accuracyexplainable deep learninguncertainty estimation

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Area of Science:

  • Biomedical Engineering
  • Artificial Intelligence
  • Machine Learning

Background:

  • Biosignal analysis often relies on complex models lacking interpretability.
  • There is a need for AI frameworks that provide transparent health assessments from physiological data.

Purpose of the Study:

  • To develop an explainable deep learning framework for transforming biosignal dynamics into interpretable health assessments.
  • To enhance adaptability and diagnostic granularity using an Adaptive Health State Inference Mechanism (AHSIM).

Main Methods:

  • The PhysioGraph Inference Network (PGIN) combines temporal graph reasoning with probabilistic modeling.
  • An Adaptive Health State Inference Mechanism (AHSIM) adjusts diagnostic granularity based on uncertainty and signal entropy.

Main Results:

  • The framework achieved superior diagnostic accuracy (up to 92.48%) and AUC (up to 93.65%) on four biosensing datasets.
  • Outperformed transformer-based baselines like RoBERTa and T5.
  • Provided transparent uncertainty estimates, demonstrating suitability for clinical and wearable applications.

Conclusions:

  • The framework successfully integrates physiological semantics and model interpretability.
  • It bridges the gap between black-box AI and trustworthy biomedical intelligence.
  • Offers a reliable solution for interpretable health assessments using biosignals.