Spontaneous remission of congenital acute megakaryoblastic leukemia in a neonate with down syndrome
Wei Yang1,2, Sumin Sui1,2, Sheng Hao1,2,3
1Department of Pediatric, The People's Hospital of Bozhou, Bozhou, China.
Objectives:
Congenital acute megakaryoblastic leukemia (AMKL) is an extremely rare and aggressive malignancy with poor prognosis.
Case Presentation:
We report a female neonate with Down syndrome (DS) who presented with respiratory distress and hepatomegaly at birth. Laboratory evaluation revealed hyperleukocytosis (253.45 × 109/L) and bone marrow studies confirmed AMKL with trisomy 21. Remarkably, spontaneous hematologic remission occurred within 2 months without chemotherapy.
Conclusions:
This case highlights the unique clinical course of DS-associated AMKL and underscores the potential for spontaneous regression in congenital leukemia.
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