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Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

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Patching Peripheral Retinal Breaks on Atrophic Choroid: A Prospective Pilot Study to Prevent Redetachment.

Barbara Parolini¹, Aurelio Apuzzo², Antonio Spinelli³

¹Department of Ophthalmology, Eyecare Clinic, Brescia, Italy.

Journal of Vitreoretinal Diseases

|March 2, 2026

Summary

This summary is machine-generated.

Bovine pericardium (Tutopatch) effectively seals retinal breaks in highly myopic eyes with chorioretinal atrophy. This innovative treatment promotes retinal reattachment and visual acuity improvement, offering a new option where conventional methods fail.

Keywords:

Tutopatch chorioretinal atrophy myopia retinal detachment silicone oil tamponade vitrectomy

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Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate

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Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate

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Published on: September 11, 2013

Area of Science:

Ophthalmology
Retinal Surgery
Biomaterials in Medicine

Background:

Peripheral retinal breaks over chorioretinal atrophy in highly myopic eyes present surgical challenges.
Conventional treatments may be limited in these specific anatomical conditions.

Purpose of the Study:

To assess the efficacy and safety of using bovine pericardium (Tutopatch) as a sealant for retinal breaks.
To evaluate Tutopatch in highly myopic eyes with retinal detachment (RD) over areas of chorioretinal atrophy.

Main Methods:

A 25-gauge pars plana vitrectomy with subretinal fluid drainage and silicone oil (SO) tamponade was performed.
A trimmed Tutopatch was applied over the retinal breaks in seven highly myopic eyes.
Follow-up included best-corrected visual acuity (BCVA), intraocular pressure (IOP), fundus photography, and widefield optical coherence tomography over 12 months.

Main Results:

Complete retinal reattachment was achieved in all seven eyes, with no recurrence after SO removal.
Median BCVA improved significantly from 0.10 (20/200) to 0.20 (20/100).
The Tutopatch remained well-adherent without inflammation or complications, and mean IOP showed a slight increase.

Conclusions:

Tutopatch is a safe and effective option for sealing retinal breaks in challenging locations like chorioretinal atrophy in highly myopic eyes.
This technique shows promise in preventing redetachment in this patient population.
Larger studies are recommended to validate these findings.