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Related Experiment Video

Updated: Mar 3, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

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Visible light optical coherence tomography for assessing retinal structure and function in diseased mouse models.

Qianyue Gu1, Wenbo Xiu2, Songzhi Wu1

  • 1School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, China.

Biomedical Optics Express
|March 2, 2026
PubMed
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A new visible light optical coherence tomography (OCT) system enables high-definition 3D imaging of mouse retinas. This technology aids in understanding blinding eye diseases like retinitis pigmentosa and glaucoma.

Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Medical Imaging

Background:

  • Early diagnosis of blinding eye diseases relies on precise measurement of retinal structure and function.
  • Current imaging techniques may have limitations in resolution and functional assessment.

Purpose of the Study:

  • To develop and evaluate a visible light optical coherence tomography (OCT) system for high-definition 3D retinal imaging in mouse models.
  • To assess retinal structure, blood flow, and oxygen saturation in disease models.

Main Methods:

  • Development of a visible light OCT system integrating high-resolution imaging, GPU-accelerated computing, and automated retinal layer segmentation.
  • Imaging of retinitis pigmentosa and glaucoma mouse models, compared to wild-type controls.
  • Histological analysis for validation of OCT findings.

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Related Experiment Videos

Last Updated: Mar 3, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

3.6K
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

5.4K
Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

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Main Results:

  • Visible light OCT revealed reduced retinal thickness and specific layer damage in retinitis pigmentosa models.
  • Glaucoma models showed reduced ganglion cell layer intensity.
  • Both disease models displayed altered retinal blood flow and oxygen saturation patterns.

Conclusions:

  • Visible light OCT provides detailed 3D retinal imaging and functional assessment in mouse models.
  • This technology offers new avenues for studying ocular disease pathology and monitoring therapeutic interventions.