Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The efficacy and safety of darolutamide combination therapy in advanced prostate cancer: a systematic review and meta-analysis of randomized controlled trials.

Frontiers in pharmacology·2026
Same author

Dual-frequency fiber-array photoacoustic computed tomography for high-resolution deep brain imaging.

Light, science & applications·2026
Same author

All-fiber photoacoustic endomicroscopy reveals layer-specific angiogenesis-oxygenation uncoupling in experimental colitis.

Science advances·2026
Same author

A wearable fiber-optoacoustic interface for continuous deep-tissue hemodynamics in MRI environments.

Photoacoustics·2026
Same author

Multifunctional fiber-optic theranostic probe for closed-loop tumor photothermal therapy.

Light, science & applications·2026
Same author

Cross-tissue integrative transcriptomic and multimodal analyses suggest shared immune signatures linking lupus nephritis and cutaneous lupus erythematosus.

Frontiers in immunology·2026

Related Experiment Video

Updated: Jun 25, 2026

Three-dimensional Optical-resolution Photoacoustic Microscopy
08:31

Three-dimensional Optical-resolution Photoacoustic Microscopy

Published on: May 3, 2011

19.0K

Phase-coherent multi-sensor synthesis for enhanced photoacoustic imaging: a comprehensive framework for optimal

Chaoneng Wu1, Wei Li1, Yizhi Liang1

  • 1Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, College of Physics and Optoelectronics, Jinan University, Guangzhou 510632, China.

Biomedical Optics Express
|March 2, 2026
PubMed
Summary

This study introduces a new method for combining data from multiple photoacoustic imaging sensors. The technique significantly improves image resolution and signal quality, enabling clearer visualization of blood vessels.

More Related Videos

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
11:21

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Published on: January 15, 2013

12.0K
Switchable Acoustic and Optical Resolution Photoacoustic Microscopy for In Vivo Small-animal Blood Vasculature Imaging
10:17

Switchable Acoustic and Optical Resolution Photoacoustic Microscopy for In Vivo Small-animal Blood Vasculature Imaging

Published on: June 26, 2017

12.5K

Related Experiment Videos

Last Updated: Jun 25, 2026

Three-dimensional Optical-resolution Photoacoustic Microscopy
08:31

Three-dimensional Optical-resolution Photoacoustic Microscopy

Published on: May 3, 2011

19.0K
Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
11:21

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Published on: January 15, 2013

12.0K
Switchable Acoustic and Optical Resolution Photoacoustic Microscopy for In Vivo Small-animal Blood Vasculature Imaging
10:17

Switchable Acoustic and Optical Resolution Photoacoustic Microscopy for In Vivo Small-animal Blood Vasculature Imaging

Published on: June 26, 2017

12.5K

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Acoustics

Background:

  • Photoacoustic imaging (PAI) offers high resolution and contrast for visualizing biological tissues.
  • Expanding the effective bandwidth of acoustic detection is crucial for improving PAI resolution.
  • Current methods for multi-sensor data integration often fail to fully leverage complementary sensor characteristics.

Purpose of the Study:

  • To develop a phase-coherent multi-sensor synthesis framework for photoacoustic imaging.
  • To enhance the effective bandwidth of acoustic detection in PAI systems.
  • To improve spatial resolution and signal-to-noise ratio (SNR) for detailed vascular visualization.

Main Methods:

  • Integration of precise point spread function characterization.
  • Application of phase-aware deconvolution techniques.
  • Adaptive signal synthesis optimizing complementary sensor frequency responses.
  • Utilized two optical fiber sensors with distinct diameters (125 µm and 90 µm) and resonant frequencies (22 MHz and 31 MHz).

Main Results:

  • Phase-corrected synthesis significantly outperformed direct signal addition.
  • Achieved enhanced spatial resolution, improving from 170 µm to 83 µm.
  • Demonstrated a 6 dB improvement in signal-to-noise ratio (SNR).
  • Enabled simultaneous visualization of vessels across different scales with improved clarity in phantom and in vivo experiments.

Conclusions:

  • The developed framework provides a practical approach for phase-coherent multi-sensor synthesis in PAI.
  • The method enhances spatial resolution and SNR, leading to superior vascular imaging.
  • This generalizable framework offers a versatile solution for clinical PAI applications requiring detailed vascular visualization.