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Plasma CA125 Levels as a Predictor of Major Adverse Cardiac Events in Patients With Acute Coronary Syndrome: A

Nazlı Dilek Çolak1, Turgut Karabağ2, Onuralp Çalışkan3

  • 1Clinical Pharmacy, Marmara University, Institute of Health Sciences, 34854, Istanbul, Turkey.

Journal of the Saudi Heart Association
|March 2, 2026
PubMed

Insights

Carbohydrate antigen 125 (CA125) levels correlate with cardiac biomarkers in acute coronary syndrome (ACS) patients. Elevated CA125 may predict major adverse cardiac events (MACE) within six months.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Research

Background:

  • Carbohydrate antigen 125 (CA125) is linked to cardiovascular conditions.
  • Understanding CA125's role in acute coronary syndrome (ACS) is crucial.

Purpose of the Study:

  • To determine CA125 levels in ACS patients.
  • To investigate the relationship between CA125 and major adverse cardiac events (MACE) in the short term.

Main Methods:

  • Prospective cohort study in a coronary care unit.
  • Plasma CA125 measured upon admission; patients followed for six months.
  • MACE included mortality, recurrent ACS, revascularization, heart failure, stroke, and atrial fibrillation.

Main Results:

  • 127 ACS patients included; median CA125 was 14.6 KU/L.
  • CA125 positively correlated with hs-cTn and pro-BNP.
  • CA125 showed a weak negative correlation with left ventricular ejection fraction (LVEF).

Conclusions:

  • Plasma CA125 correlates with established ACS biomarkers (pro-BNP, hs-cTn).
  • Elevated CA125 may identify ACS patients at higher risk for short-term MACE.
  • CA125 warrants further investigation as a prognostic marker in ACS.
Abstract

Keywords:
Acute coronary syndromeBiomarkerCarbohydrate antigen 125Cardiovascular diseasesMajor cardiac adverse events

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