Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.8K
3.8K
Bipolar Disorder01:30

Bipolar Disorder

1.2K
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
1.2K
Aging01:26

Aging

917
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
917
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

13.6K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
13.6K
Human Genetics01:28

Human Genetics

1.8K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The relevance of phenotypic definition in treatment resistant forms of major depressive disorder: a narrative review.

Frontiers in pharmacology·2026
Same author

Mechanisms of weight gain associated with valproic acid: a scoping review.

European archives of psychiatry and clinical neuroscience·2026
Same authorSame journal

Bipolar disorder and somatic diseases: Focus on oxidative stress markers.

Neuroscience applied·2026
Same author

Correction: Thyroid peroxidase antibodies in bipolar disorder: implications for clinical sub-phenotypes and lithium response.

International journal of bipolar disorders·2026
Same author

Integrating Genetic Variants and Expression Profiles of Pharmacogenes to Investigate Resistance to Antidepressant Treatment.

Medicina (Kaunas, Lithuania)·2026
Same author

DNA methylation signatures associated with bipolar disorder in peripheral blood improve prediction models.

EBioMedicine·2026

Related Experiment Video

Updated: Mar 3, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.5K

Long non-coding RNAs and accelerated aging in bipolar disorder.

Sultan Ekinci1, Hidayet Ece Arat Çelik2, İbrahim Fettahoğlu3

  • 1Suruç State Hospital, Republic of Türkiye Ministry of Health, Şanlıurfa, Turkey.

Neuroscience Applied
|March 2, 2026
PubMed
Summary

Long non-coding RNAs (lncRNAs) may link bipolar disorder (BD) to accelerated aging. This review identifies several lncRNAs implicated in both aging and BD, highlighting areas for future research.

Keywords:
Accelerated agingAging-associated neuropsychiatric disordersBipolar disorderLong non-coding RNAs

More Related Videos

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
07:14

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

Published on: February 25, 2022

6.6K
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.4K

Related Experiment Videos

Last Updated: Mar 3, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.5K
Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
07:14

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

Published on: February 25, 2022

6.6K
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.4K

Area of Science:

  • Genetics
  • Molecular Biology
  • Neuroscience

Background:

  • Bipolar disorder (BD) is linked to accelerated biological aging.
  • Long non-coding RNAs (lncRNAs) regulate aging processes and epigenetics.
  • lncRNAs may mediate the connection between BD and accelerated aging.

Purpose of the Study:

  • To review current evidence on aging-associated lncRNAs.
  • To assess the relevance of these lncRNAs to bipolar disorder (BD).

Main Methods:

  • Systematic literature search of PubMed up to June 2, 2025.
  • Keywords included lncRNAs, aging mechanisms, and neuropsychiatric disorders.
  • Analysis of 112 articles reporting 163 lncRNAs.

Main Results:

  • 19 lncRNAs were common to aging mechanisms and neuropsychiatric disorders.
  • Six lncRNAs (ANRIL, HOTAIR, TUG1, MALAT1, NEAT1, GAS5) were reported in both aging and BD contexts.
  • Further validation is needed for these lncRNAs in BD.

Conclusions:

  • Specific lncRNAs are implicated in both aging and BD.
  • These lncRNAs warrant further investigation as potential contributors to BD pathophysiology.
  • Additional lncRNAs may represent novel targets for future BD research.