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Zn(II)-Responsive Peptide Hydrogels with Tunable Mechanical Properties.

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This study shows how zinc ions (Zn-(II)) can make short peptides form hydrogels. These metal-coordinated peptide assemblies offer potential for advanced biomaterials and injectable carriers.

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Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Supramolecular Chemistry

Background:

  • Metal-coordinated peptide assemblies are promising for creating functional biomaterials.
  • Hydrogelation of peptides using metal ions offers tunable properties for advanced applications.

Purpose of the Study:

  • To investigate zinc ion (Zn-(II))-driven hydrogelation of short amphiphilic peptides.
  • To characterize the resulting metallo-hydrogels and assess their potential in biomaterials.

Main Methods:

  • Synthesis of amphiphilic hexapeptides using solid-phase peptide synthesis.
  • Characterization of hydrogel formation and structure using circular dichroism (CD), FTIR, TEM, and SEM.
  • Evaluation of mechanical properties via oscillatory rheology and thixotropy measurements.

Main Results:

  • Zn-(II) induced the formation of metallo-hydrogels from short amphiphilic peptides.
  • Rheology confirmed viscoelastic and shear-recoverable properties, with Zn-(II) enhancing mechanical robustness.
  • Moderate antibacterial activity against *Escherichia coli* and *Staphylococcus aureus* was observed.

Conclusions:

  • Zn-(II)-responsive assembly of short amphiphilic peptides creates functional hydrogels.
  • The hydrogels exhibit properties suitable for injectable carriers and 3D printing bioinks.
  • This work lays the foundation for developing novel Zn-(II)-coordinated peptide-based biomaterials.