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Nucleic acid-based therapeutics to restore joint homeostasis in age-related and post-traumatic arthritis
Muhammad Farooq Rai1,2,3,4, Christine Tn Pham3, Kirk Hou5
1Department of Biological Sciences, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, UAE.
Abstract:
Osteoarthritis, a complex genetic disease, involves disrupted joint homeostasis driven by catabolic and inflammatory processes. Traditional therapies offer limited success. This review explores nucleic acid-based therapeutics-siRNA, miRNA, and mRNA-as a promising strategy for restoring balance by modulating gene expression. Nanoplatforms enable precise delivery of these molecules, offering potential for disease-modifying interventions. Emphasis is placed on advancing RNA therapies tailored to the disease stage for effective disease management.
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