Artificial intelligence in Combating Antimicrobial Resistance
Natto Hatim A1, Mahmood Ammar Abdul Razzak2, T Sriram3
1Department of Public Health, Umm Al-Qura University, Makkah, Saudi Arabia.
Abstract:
Antibiotic resistance (AR) has become a significant worldwide public health concern in the twenty-first century. Antimicrobial resistance (AMR) occurs when microorganisms, such as bacteria, fungi, parasites, and viruses acquire genetic changes that make them resistant to antimicrobial drugs, including antibiotics. AMR, often known as the "Silent Pandemic," requires prompt and persistent intervention rather than postponement. Failure to take preventative measures will result in AMR becoming the primary cause of mortality worldwide. In the fight against multidrug-resistant bacteria to halt antibiotic resistance, conventional techniques for developing drugs are expensive and time-consuming. However, AI systems can rapidly scan extensive chemical libraries and forecast possible antibacterial agents. Considering the slow progress of ongoing antibiotic research, it is essential to accelerate the development of novel antibiotics and supplementary treatments. The acceleration is essential to effectively address the increasing health risk posed by antibiotic-resistant bacteria and to ensure that we maintain an advantage in combating these emerging threats. The use of AI in medical research holds significant promise, particularly in addressing multidrug-resistant (MDR) infections to battle AMR. This study focuses on the effective applications of AI in addressing AMR and its potential benefits for humanity. It covers fundamental concepts of AI, current available resources for AI, its uses and scope, as well as its benefits and limitations.AI algorithms consistently observe antibiotic usage, diseases occurrences, and resistance trends. This review explores how AI is used to identify AMR markers, diagnose AMR, develop smallmolecule antibiotic and also emphasizes emerging research domains, such as AMR detection and novel medication development, which contribute to managing AMR.
Insights
Artificial intelligence (AI) accelerates the discovery of new antibiotics to combat antimicrobial resistance (AMR), a growing global health threat. AI offers a faster, more efficient approach to developing novel treatments against drug-resistant bacteria.
Area of Science:
- Microbiology
- Computational Biology
- Public Health
Background:
- Antimicrobial resistance (AMR) is a critical global health issue, often termed the "Silent Pandemic."
- Conventional antibiotic development is slow and costly, hindering progress against multidrug-resistant (MDR) bacteria.
- Failure to address AMR could lead to it becoming the leading cause of mortality worldwide.
Purpose of the Study:
- To explore the effective applications of Artificial Intelligence (AI) in combating AMR.
- To highlight the potential benefits of AI in accelerating the development of novel antibiotics and treatments.
- To provide an overview of AI concepts, resources, uses, scope, benefits, and limitations in the context of AMR.
Main Methods:
- Review of AI applications in identifying AMR markers.
- Analysis of AI's role in diagnosing AMR and developing small-molecule antibiotics.
- Exploration of AI in emerging research domains like AMR detection and novel drug development.
Main Results:
- AI systems can rapidly screen chemical libraries to identify potential antibacterial agents.
- AI algorithms analyze antibiotic usage, disease occurrences, and resistance trends to inform AMR strategies.
- AI shows promise in accelerating the development of new antibiotics and supplementary treatments for MDR infections.
Conclusions:
- AI offers a powerful and efficient tool to accelerate the fight against antimicrobial resistance.
- The integration of AI in medical research is crucial for developing novel antibiotics and managing AMR.
- AI applications are vital for maintaining an advantage against emerging threats posed by antibiotic-resistant bacteria.
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