Invasive Lobular Carcinoma of the Male Breast With BRCA2 Mutation

Area of Science:

• Oncology
• Genetics
• Pathology

Background:

• Male breast cancer (MBC) is rare, <1% of all breast cancers.
• Bilateral synchronous MBC is exceptionally uncommon.
• Lobular carcinoma in males is rare, 1-2% of MBC cases.

Purpose of the Study:

• To report an extremely rare case of bilateral synchronous male breast cancer.
• To highlight the occurrence of both invasive ductal and lobular carcinoma in the same patient.
• To discuss the implications of a BRCA2 mutation in male breast cancer.

Main Methods:

• Case presentation of an elderly male patient with bilateral breast masses.
• Diagnostic workup including imaging and biopsy.
• Genetic testing for BRCA2 mutation.
• Surgical management for bilateral breast cancer.

Main Results:

• Diagnosis of invasive ductal carcinoma (left breast) and invasive lobular carcinoma (right breast).
• Identification of a pathogenic BRCA2 gene mutation (c.331_347delinsC).
• Successful simultaneous surgery for bilateral disease.

Conclusions:

• This case underscores the possibility of synchronous bilateral male breast cancer with different histological types.
• BRCA2 mutations should be considered in male breast cancer patients, especially with a family history.
• Management decisions, including adjuvant therapy, require careful consideration of patient age and overall health.