Current landscape of single-cell genomics in meningioma

Meningiomas are the most common primary intracranial tumor in adults. Traditional bulk genomic and histopathological analyses have provided valuable insights into meningioma biology. Recent advances in single-cell sequencing technologies have enabled the comprehensive study of a tumor's transcriptome and epigenome at a single-cell resolution, along with spatially resolved data and functional genomics approaches. These strategies allow for the profiling of complex intratumoral and intertumoral heterogeneity, the identification of gene regulatory networks, and the characterization of distinct cell populations within the tumor microenvironment that drive tumor behavior. In this review, we examine the current landscape of single-cell omics in meningioma research and highlight opportunities for future discovery.