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Malignant Phosphaturic Mesenchymal Tumor With Lung Metastasis
Seden Arsoy Sahin1, Cem Comunoglu1, Sevda Karyagar2
1Pathology, Prof. Dr. Cemil Taşcıoğlu City Hospital, Istanbul, TUR.
Cureus
|March 2, 2026
Summary
Malignant phosphaturic mesenchymal tumors (MPMT) are rare soft tissue neoplasms causing hypophosphatemia. This case highlights a patient diagnosed with MPMT via next-generation sequencing, who later developed lung metastasis.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Malignant phosphaturic mesenchymal tumors (MPMT) are rare soft tissue neoplasms.
- MPMTs are associated with tumor-induced osteomalacia and hypophosphatemia.
- Characteristic FN1::FGFR1/FGF1 gene fusions are observed in these tumors.

