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The Triglyceride-Glucose Index is associated with hospital and Intensive Care Unit Mortality in critically ill

Zihuai Huang1, Qianqian Zou2, Ya Lin3

  • 1Orthopedics Department, Wenzhou Peoples' Hospital, Wenzhou, Zhejiang, China.

Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences
|March 2, 2026
PubMed

Insights

The triglyceride-glucose (TyG) index can predict mortality in critically ill patients with acute coronary syndrome (ACS). Higher TyG index values are linked to increased hospital and intensive care unit (ICU) mortality risks.

Area of Science:

  • Cardiology
  • Critical Care Medicine
  • Biochemistry

Background:

  • Acute coronary syndrome (ACS) is a major cause of mortality globally.
  • Effective risk stratification for ACS patients remains a critical challenge.
  • Limited attention has been given to predictive markers for ACS patient outcomes.

Purpose of the Study:

  • To evaluate the predictive utility of the triglyceride-glucose (TyG) index.
  • To assess the association between the TyG index and mortality in critically ill ACS patients.
  • To determine if the TyG index can serve as a risk stratification tool for ACS.

Main Methods:

  • Utilized data from the eICU Collaborative Research Database.
  • Calculated the TyG index using fasting glucose and triglyceride levels.
  • Employed logistic regression, subgroup analysis, and graphical methods to analyze hospital and ICU mortality endpoints.

Main Results:

  • Included 5237 critically ill ACS patients.
  • Demonstrated significantly higher TyG index values in non-survivors compared to survivors.
  • Confirmed TyG index as a significant independent predictor of both hospital and ICU mortality across various analyses.

Conclusions:

  • The triglyceride-glucose (TyG) index is a valuable and independent predictor.
  • TyG index aids in risk stratification for critically ill patients with ACS.
  • This index can help identify patients at higher risk of mortality.
Abstract

Keywords:
Acute coronary syndromeglucosemortalityprognosistriglycerides

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