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Modulation of neuronal synchrony by population-level inhibitory delayed feedback
Parnia Hatamian1, Massoud Reza Hashemi1, Mojtaba Madadi Asl2,3
1Department of Electrical and Computer Engineering, Isfahan University of Technology, Isfahan, Iran.
Chaos (Woodbury, N.Y.)
|March 2, 2026
Summary
Delayed inhibitory feedback significantly impacts neuronal synchrony in excitatory networks. Intermediate delays enhance synchrony in active states, while desynchronized states show minimal effects, revealing dynamic control mechanisms.
Area of Science:
- Computational Neuroscience
- Systems Neuroscience
- Neurodynamics
Background:
- Neuronal synchrony is crucial for brain function and dysfunction.
- Delayed interactions and inhibitory control are key regulators of synchrony.
- Understanding inhibitory feedback's role is vital for brain dynamics.
Purpose of the Study:
- To investigate how delayed inhibitory feedback modulates synchrony in an excitatory network.
- To explore the influence of feedback delay on network synchronization.
- To determine the effect of inhibitory feedback on network states and bistability.
Main Methods:
- Simulated Hodgkin-Huxley neurons coupled via delayed conductance-based synapses.
- Analysis of network activity under varying inhibitory feedback delays.
- Investigated the impact of external stimuli on network synchrony.
Main Results:
- Delayed inhibitory feedback's effect on synchrony is state-dependent.
- Intermediate delays enhance synchrony in synchronized and transitional states.
- Desynchronized states show minimal modulation by inhibitory feedback.
- Inhibitory feedback is necessary to maintain synchrony initiated by external pulses.
Conclusions:
- Population-level inhibitory feedback with delay dynamically controls network synchrony.
- Delayed inhibition can induce bistable network behavior.
- Inhibitory circuits play a critical role in stabilizing or disrupting cortical network oscillations.
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