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Related Concept Videos

Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

438
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
438
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

526
Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
526
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

432
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
432
Pericarditis IV: Nursing Management01:25

Pericarditis IV: Nursing Management

474
Pericarditis, an inflammation of the pericardium, necessitates diligent nursing management to ensure effective patient care and recovery. The initial step in managing pericarditis is a comprehensive patient medical assessment.The patient reports chest pain aggravated by breathing, coughing, and swallowing, which worsens when lying supine. The pain often improves when sitting up and leaning forward. Additional symptoms may include fever, malaise, and, in severe cases, signs of heart failure.
474
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

266
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
266
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

388
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
388

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Related Experiment Video

Updated: Mar 3, 2026

An Intact Pericardium Ischemic Rodent Model
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Pericarditis With Early Effusive-Constrictive Physiology After Immune Checkpoint Inhibitor Therapy.

Mohammed Ali1, Emanuel Irizarry Berríos2, Christopher K Heinrich2

  • 1Rush Medical College, Rush University Medical Center, Chicago, Illinois, USA.

JACC. Case Reports
|March 2, 2026
PubMed
Summary

Immune checkpoint inhibitor (ICI) therapy can rarely cause effusive-constrictive pericarditis. Prompt diagnosis and treatment of this cardiac complication are crucial for patient outcomes.

Area of Science:

  • Cardiology
  • Oncology
  • Immunology

Background:

  • Immune checkpoint inhibitors (ICIs) are associated with cardiac complications, including pericarditis.
Keywords:
autoimmuneconstrictive pericarditisimmune check point inhibitor

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  • Effusive-constrictive pericarditis, a rare manifestation, involves pericardial inflammation and fibrosis.
  • This case highlights early effusive-constrictive physiology following combination ICI therapy.