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A Vaccine to Prevent Congenital Cytomegalovirus: Where Do We Go Next?

Mark R Schleiss1, Stanley A Plotkin2,3, Sallie R Permar4

  • 1Division of Pediatric Infectious Diseases and Immunology, University of Minnesota, Minneapolis.

JAMA Pediatrics
|March 2, 2026
PubMed
Abstract

No abstract available in PubMed .

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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