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Research progress of sepsis immunotherapy: a bibliometric analysis.
Zixia Wang1, Xiangyang Li, Junqiang Zhang
1Intensive Care Unit, The Second Hospital and Clinical Medical School, Lanzhou University, 82 Cuiyingmen, Lanzhou, Gansu Province, China.
Shock (Augusta, Ga.)
|March 2, 2026
Summary
Sepsis immunotherapy research is rapidly expanding, evolving from anti-inflammatory strategies to precision medicine. Future efforts require global collaboration and biomarker-driven treatments for improved clinical outcomes.
Area of Science:
- Immunology
- Critical Care Medicine
- Bibliometrics
Background:
- Sepsis causes organ failure and high mortality due to immune system dysfunction.
- Research focuses on immunotherapy to restore immune balance.
- This study maps the evolving research landscape of sepsis immunotherapy.
Purpose of the Study:
- To conduct a bibliometric analysis of sepsis immunotherapy research.
- To identify trends, key players, and research phases.
- To understand the global research landscape and collaboration patterns.
Main Methods:
- Bibliometric analysis of 768 papers (2000-2025) from Web of Science Core Collection.
- Utilized VOSviewers, CiteSpace, Scimago Graphica, Charticulator, and R bibliometrix.
- Analyzed publication trends, collaboration networks, and keyword evolution.
Main Results:
- Sepsis immunotherapy research shows exponential growth, with the US leading in publications and influence.
- Research evolved through distinct phases: anti-inflammatory, cellular, and integrated immunomodulation.
- Key publications include the Sepsis-3 Consensus, highlighting foundational knowledge.
Conclusions:
- Sepsis immunotherapy research is advancing rapidly towards personalized, biomarker-based treatments.
- Enhanced international cooperation and translational research are crucial for future progress.
- Future directions include immune checkpoint inhibitors and multi-omics integration for tailored therapies.
