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Osteoarticular involvement in pediatric brucellosis: A 15-year retrospective study from a tertiary care pediatric

Arife Özer1, Gizem Güner Özenen1, Aybüke Akaslan Kara1

  • 1Department of Pediatric Infectious Diseases, University of Health Sciences Dr. Behçet Uz Children's Hospital, Izmir, 35210, Turkey.

Journal of Tropical Pediatrics
|March 2, 2026
PubMed

Insights

Pediatric brucellosis with osteoarticular involvement presents with myalgia and back pain. Early evaluation for joint complications in endemic areas is crucial for effective treatment and preventing long-term issues.

Area of Science:

  • Infectious Diseases
  • Pediatrics
  • Rheumatology

Background:

  • Brucellosis is a significant public health concern in tropical and endemic regions.
  • Osteoarticular involvement is a common complication of pediatric brucellosis.
  • Understanding the characteristics and risk factors of pediatric osteoarticular brucellosis is essential for timely diagnosis and management.

Purpose of the Study:

  • To evaluate demographic, clinical, laboratory, and radiological features of pediatric brucellosis patients.
  • To compare characteristics between patients with and without osteoarticular involvement.
  • To identify risk factors and outcomes associated with pediatric osteoarticular brucellosis.

Main Methods:

  • Retrospective analysis of 101 pediatric brucellosis patients diagnosed between 2008 and 2022.
  • Data collected from patient files and electronic health records.
  • Patients categorized based on the presence or absence of osteoarticular involvement.

Main Results:

  • 51.5% of pediatric brucellosis patients had osteoarticular involvement.
  • Myalgia, low back pain, and higher agglutination titers were associated with osteoarticular involvement.
  • Delayed hospital admission was observed in patients with osteoarticular brucellosis.

Conclusions:

  • Children in endemic areas with myalgia, back pain, and high agglutination titers require careful evaluation for osteoarticular brucellosis.
  • Early diagnosis of osteoarticular brucellosis in children is vital for preventing complications.
  • Prompt treatment is essential for optimizing outcomes in pediatric brucellosis patients with joint involvement.

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