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Bridging the Bio-Electronic Interface with Biofabrication
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Technology Roadmap of Bioinspired Computing Hardware
Shuang Wang1,2,3, Zhiyuan Li1,2,3, Mengjiao Pei1,2,3
1Department of Applied Physics, The Hong Kong Polytechnic University, Kowloon, Hong Kong 999077, China.
ACS Nano
|March 2, 2026
Summary
Bioinspired computing (BIC) offers a solution to artificial intelligence (AI) hardware limitations by mimicking biological systems. This roadmap details BIC
Area of Science:
- Cross-disciplinary research at the intersection of materials science, device physics, neuroscience, computer science, mathematics, and information science.
Background:
- Rapid artificial intelligence (AI) growth faces hardware bottlenecks in computation throughput and energy efficiency.
- Bioinspired computing (BIC) leverages biological system advantages like parallelism, adaptability, and robustness as a potential alternative.
Purpose of the Study:
- To provide a comprehensive roadmap for the development of Bioinspired Computing (BIC) hardware.
- To analyze frontier issues, latest progress, and critical challenges in BIC hardware development.
Main Methods:
- Categorization of challenges into hardware foundations, architectures, and prototype realizations.
- Highlighting biological features inspiring BIC hardware design through device physics.
- Describing signaling rules and structural organizations in BIC architectures for computational prototypes.
Main Results:
- Discussion of performance metrics and engineering challenges for BIC hardware.
- Presentation of electronic and photonic BIC chip prototypes.
- A technological roadmap outlining opportunities for expanding BIC hardware functionality.
Conclusions:
- Interdisciplinary convergence is crucial for advancing BIC hardware.
- Coordinated advances in devices, architectures, and system demonstrations can accelerate the shift to high-efficiency AI hardware.
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