Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Proteomics01:33

Proteomics

7.5K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implantable Cardioverter-Defibrillator Therapy in Contemporary Heart Failure Patients: An Analysis From the EMPEROR-Reduced Trial.

JACC. Heart failure·2026
Same author

Systolic blood pressure and albuminuria reduction mediate cardiovascular benefits of finerenone in T2 diabetes and CKD.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same author

Longitudinal loop diuretic use in patients with HFrEF initiated with sodium-glucose cotransporter 2 inhibitors.

European heart journal. Cardiovascular pharmacotherapy·2026
Same author

Predicted versus observed outcomes in the ALT-FLOW early feasibility study.

ESC heart failure·2026
Same author

Comparative analysis of randomized versus real-world populations in heart failure: DIAMOND trial vs CARE-HK registry.

ESC heart failure·2026
Same author

Optimal serum potassium concentrations in heart failure: an individual patient data meta-analysis.

European heart journal·2026
Same journal

"Reply to Murthy et al. regarding AI-derived LVOT-VTI for monitoring disease progression in transthyretin cardiac amyloidosis".

European journal of heart failure·2026
Same journal

High serum transthyretin concentrations identify a low likelihood of advanced myocardial amyloid burden in suspected ATTR cardiomyopathy.

European journal of heart failure·2026
Same journal

Consistent Efficacy of Vutrisiran Across Sexes in Transthyretin Cardiac Amyloidosis: Evidence from the HELIOS-B Trial.

European journal of heart failure·2026
Same journal

Time-dependent effects of interleukin-1 blockade by anakinra in myocarditis and inflammatory cardiomyopathy.

European journal of heart failure·2026
Same journal

Does Phenotypic Heterogeneity in Heart Failure With Preserved Ejection Fraction Imply Mechanistic Heterogeneity? The Myth of a Phenotype-Directed Therapeutic Framework and the Mandate for a Falsifiable Hypothesis.

European journal of heart failure·2026
Same journal

Letter regarding the article "Independent and Dose-Dependent Contributions of Clonal Hematopoiesis and Mosaic Loss of Y to Incident Heart Failure".

European journal of heart failure·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

1.2K

Proteomic patterns according to ejection fraction: an EMPEROR-programme analysis.

João Pedro Ferreira1,2, Francesco Fioretti3,4, Mikhail Sumin5

  • 1RISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto 4200-319, Portugal.

European Journal of Heart Failure
|March 2, 2026
PubMed
Summary
This summary is machine-generated.

Proteomic biomarkers show trends across left ventricular ejection fraction (LVEF) categories in heart failure patients. However, circulating proteins weakly correlate with LVEF and do not reliably discriminate ejection fraction levels.

Keywords:
Ejection fractionHeart failureProteomics

More Related Videos

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
09:00

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

Published on: April 18, 2025

1.4K
Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools
07:01

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

1.2K

Related Experiment Videos

Last Updated: May 4, 2026

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

1.2K
A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
09:00

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

Published on: April 18, 2025

1.4K
Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools
07:01

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

1.2K

Area of Science:

  • Cardiology
  • Proteomics
  • Biomarker Discovery

Background:

  • Left ventricular ejection fraction (LVEF) is a key criterion in heart failure (HF) trials.
  • Patient characteristics, risk, and treatment response differ across LVEF.
  • Understanding biological processes related to LVEF is crucial.

Purpose of the Study:

  • To investigate proteomic biomarker expression across different LVEF categories.
  • Utilize data from the EMPEROR-Programme to analyze protein expression patterns.
  • Identify potential protein biomarkers associated with LVEF variations.

Main Methods:

  • Analysis of proteomic data from 2254 patients using Olink® platforms.
  • Focus on the EMPEROR-Preserved dataset for main analyses.
  • Ordinal logistic regression used to compare protein concentrations across LVEF categories (41%-49%, 50%-59%, ≥60%), adjusted for covariates and FDR correction.

Main Results:

  • 297 proteins showed expression trends across LVEF categories in EMPEROR-Preserved.
  • Top proteins included NT-pro BNP, Wnt inhibitory factor-1, and natriuretic peptides B.
  • Correlation between these proteins and LVEF was generally weak (Rho ≤0.2).

Conclusions:

  • Differentially expressed proteins suggest involvement of natriuretic peptide, cell-adhesion, and clonal hematopoiesis pathways.
  • No proteins met the 5% FDR threshold, and correlations with LVEF were weak.
  • Circulating proteins may not be effective discriminators of ejection fraction in HF.