Related Experiment Video
Updated: May 7, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
Clinical implication of the 2025 ATA risk stratification in follicular thyroid carcinoma: A comparison with the 2015
Hyunju Park1, Bo Ram Kim2, Ji Hyun Yoo2
1Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea.
Background:
The 2025 American Thyroid Association (ATA) guideline introduced substantial updates, including separate categorization for follicular thyroid carcinoma (FTC) and revision of the traditional three-tiered system to a four-tiered system. In this study, we aimed to evaluate the predictive performance of the 2025 ATA risk stratification compared with the 2015 system in patients with FTC.
Methods:
A total of 347 patients with FTC who underwent thyroidectomy at a tertiary hospital in Seoul, Korea between August 1995 and April 2021 were evaluated. Disease-free survival (DFS) was analyzed using the Kaplan-Meier method, and proportions of variance explained (PVEs) were calculated to compare predictive accuracy.
Results:
Under the 2015 ATA system, 204, 71, and 72 patients were categorized as low, intermediate, and high risk, respectively. Applying the 2025 system, 39 of 204 low-risk patients (19.2%) were upstaged. Among 71 intermediate-risk patients, two (2.8%) were reclassified into the intermediate-high group, and four (5.6%) were upstaged to the high-risk group. The PVEs for predicting DFS were 19.99% for the 2015 system and 23.10% for the 2025 system.
Conclusions:
The 2025 ATA risk stratification system resulted in frequent upstaging compared with the 2015 system and demonstrated improved predictive performance for DFS.
Related Concept Videos
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Hyperthyroidism I: Introduction
Hyperthyroidism II: Pathophysiology
Graves' Disease I: Introduction

