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Irisin and the kidney: Key points to know?
Danilo Candido de Almeida1, Juan Sebastian Henao Agudelo2
1Federal University of São Paulo, School of Medicine, Division of Nephrology , São Paulo, Brazil.
Abstract:
Irisin, a myokine generated through the proteolytic cleavage of fibronectin type III domain-containing protein 5 (FNDC5), has been increasingly recognized as a critical mediator of the salutary effects of physical exercise on metabolic homeostasis, energy metabolism, and the regulation of inflammatory, oxidative, and fibrotic pathways. Recent investigations have delineated a significant association between irisin levels and renal pathophysiology, particularly within the context of chronic kidney disease. Emerging evidence suggests that irisin may play a modulatory role in renal function, with particular relevance to diabetic nephropathy and acute kidney injury. Therefore, this mini-review consolidates current findings on the mechanistic underpinnings of irisin's involvement in renal pathophysiology, elucidating its intricate interplay with kidney disease. Additionally, we highlight the potential of irisin as a promising biomarker and therapeutic target in nephrology.
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