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Diffuse pulmonary meningotheliomatosis in resected lung adenocarcinoma: a rare incidental finding
Hanan Mamdouh Hemead1,2, Anna Sharman3, Paul William Bishop4
1Department of Cardiothoracic Surgery, Alexandria University, Alexandria, Egypt hana_hemead@yahoo.com.
Abstract:
Diffuse pulmonary meningiotheliomatosis (DPM) and minute pulmonary menigiothelial-like nodules (MPMNs) are rare pulmonary pathologies often detected incidentally. These lesions are often benign. However, they should be considered in the differential diagnosis of pulmonary nodules. Immunohistochemical analysis established their meningothelial origin with positive reactivity to markers ubiquitously expressed in meningiomas. We present a case of a female in her late 70s who underwent lobectomy for suspected non-small cell lung cancer. Pathological assessment revealed adenocarcinoma with background of DPM. The paucity of literature warrants careful assessment and workup of these cases to exclude underlying sinister findings.
Insights
Diffuse pulmonary meningiotheliomatosis (DPM) and minute pulmonary menigiothelial-like nodules (MPMNs) are rare, benign lung lesions. This case highlights the importance of considering these in differential diagnoses, even when cancer is suspected.
Area of Science:
- Pulmonology
- Pathology
- Oncology
Background:
- Diffuse pulmonary meningiotheliomatosis (DPM) and minute pulmonary menigiothelial-like nodules (MPMNs) are rare pulmonary pathologies.
- These lesions are often incidentally detected and generally benign.
- They require consideration in the differential diagnosis of pulmonary nodules.
Purpose of the Study:
- To present a case of adenocarcinoma with background DPM.
- To emphasize the diagnostic considerations for DPM and MPMNs.
- To highlight the need for thorough workup due to limited literature.
Main Methods:
- Surgical lobectomy for suspected non-small cell lung cancer.
- Pathological assessment of resected lung tissue.
- Immunohistochemical analysis to determine lesion origin.
Main Results:
- The patient, a female in her late 70s, was diagnosed with adenocarcinoma.
- Background DPM was identified, confirming meningothelial origin via immunohistochemistry.
- The findings underscore the benign nature of DPM/MPMNs but necessitate ruling out other pathologies.
Conclusions:
- DPM and MPMNs, while rare and typically benign, must be differentiated from malignant lung nodules.
- Accurate diagnosis relies on immunohistochemical markers confirming meningothelial origin.
- Further research is warranted due to the limited literature on these conditions.
