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Related Experiment Video

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Causal association between oxidative stress and lymphomas: A two-sample Mendelian randomization study.

Bin Zhu1, Wenli Zhao1

  • 1Department of Hematology, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University South Branch (Shanghai Fengxian District Central Hospital), China.

The International Journal of Biological Markers
|March 2, 2026
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Summary

This study explored oxidative stress markers and lymphoma risk using Mendelian randomization. Myeloperoxidase (MPO) and glutathione peroxidase (GPX) were linked to follicular lymphoma, while catalase (CAT) and glutathione-S transferase (GST) showed inverse associations with lymphoma types.

Keywords:
Hodgkin lymphomaMendelian randomizationblood biomarkerscausalitynon-Hodgkin lymphoma

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Area of Science:

  • Oncology
  • Genetics
  • Biochemistry

Background:

  • Oxidative stress is implicated in cancer development, but its causal role in lymphoma pathogenesis remains unclear.
  • Understanding the relationship between oxidative stress markers and lymphoma risk is crucial for prevention and treatment strategies.

Purpose of the Study:

  • To investigate the potential causal associations between genetically predicted oxidative stress markers and the risk of developing various lymphoma subtypes.
  • To utilize a two-sample Mendelian randomization approach to assess these relationships, leveraging large-scale genome-wide association study data.

Main Methods:

  • A two-sample Mendelian randomization study design was employed.
  • Summary statistics from genome-wide association studies for oxidative stress markers and lymphoma types were utilized.
  • Inverse variance weighted method was the primary analysis, with weighted median, weighted mode, and MR-Egger regression used for confirmation and robustness checks.

Main Results:

  • Genetically predicted myeloperoxidase (MPO) showed a causal association with an increased risk of follicular lymphoma (OR=1.33).
  • Glutathione peroxidase (GPX) was also associated with follicular lymphoma (OR=1.16).
  • Catalase (CAT) and glutathione-S transferase (GST) demonstrated inverse associations with non-Hodgkin lymphoma (NHL) and follicular lymphoma, suggesting a protective effect.

Conclusions:

  • The study suggests potential causal links between specific oxidative stress markers (MPO, GPX) and increased risk of follicular lymphoma.
  • Inverse associations were observed for CAT and GST with certain lymphoma types, indicating a potential protective role.
  • Further research is needed to validate these findings, particularly addressing observed heterogeneity in some associations.