KDM6B/Pdk1 glycolytic pathway-driven ZEB2 lactylation promotes cellular cementum formation

Zhengkun Yang1, Huiyi Wang1,2, Junhong Xiao1,3

  • 1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine, Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.

Summary

Researchers discovered a new pathway involving KDM6B, PDK1, and ZEB2 lactylation that is crucial for cementum regeneration. This finding offers novel strategies for treating periodontitis and restoring lost teeth.

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