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Updated: Mar 4, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
Published on: October 25, 2013
Effects of lipid-lowering drug on vancomycin-sensitive Corynebacterium kroppenstedtii
Dong Yang1,2,3, Yanfang Zhang1,2, Ibrahima Sory Sow4,5
1Clinical Laboratory, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, China.
Background:
Granulomatous mastitis (GM) is a rare inflammatory breast disease primarily affecting reproductive-aged women with a history of breastfeeding. Within GM lesions, Corynebacterium kroppenstedtii has frequently been isolated, suggesting it may play a significant role in the development of GM. It is important to develop the novel therapeutic regimen to fight against the Corynebacterium kroppenstedtii infection.
Results:
In our study, the combination of vancomycin and the lipid-lowering drug Tetrahydrolipstatin (THL) exhibited a synergistic effect against bacteria. Proteomic analysis revealed that potential targets of THL are involved in intermediary metabolism, cellular respiration, lipid metabolism, signaling pathways, virulence, and detoxification and adaptation processes.
Conclusions:
The combination of THL and vancomycin could be a novel therapeutic regimen to enhance clinical outcomes and reduce the recurrence of GM.
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