Bakuchiol-loaded amphiphilic polymeric nanoparticles: enhancing stability and multifunctionality through...

Area of Science:

• Cosmetic Science
• Materials Science
• Biotechnology

Background:

• Bakuchiol (BK) is a natural compound with promising cosmetic properties like antioxidant and antibacterial effects.
• Its application is limited by poor solubility and chemical instability.
• Developing stable and effective delivery systems is crucial for bakuchiol's use in cosmetics.

Purpose of the Study:

• To create a stable aqueous formulation of bakuchiol using a simple nanoprecipitation method.
• To develop a delivery system that enhances bakuchiol's biological efficacy and stability.
• To evaluate the performance and safety of bakuchiol-loaded nanoparticles for dermo-cosmetic applications.

Main Methods:

• Utilized polyglyceryl-10 laurate (PG10-L), an amphiphilic polymer, for nanoparticle formulation.
• Employed a scalable nanoprecipitation strategy to encapsulate bakuchiol (BK).
• Characterized the resulting bakuchiol-loaded nanoparticles (BK@NPs) for size, encapsulation efficiency, and stability.

Main Results:

• Achieved high encapsulation efficiency (≈99%) and small particle size (<200 nm) for BK@NPs.
• Demonstrated remarkable colloidal stability of BK@NPs for over 12 weeks.
• Showcased enhanced antioxidant and antibacterial activity of BK@NPs compared to free BK.
• Confirmed excellent cytocompatibility and ROS suppression by BK@NPs in murine fibroblasts.

Conclusions:

• The PG10-L based nanoprecipitation is an efficient and scalable method for creating stable bakuchiol formulations.
• This delivery system significantly enhances bakuchiol's biological efficacy for cosmetic applications.
• The developed nanoparticles offer a promising platform for advanced dermo-cosmetic products utilizing bakuchiol's benefits.