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Colloids03:22

Colloids

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)01:16

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...
The Colloidal State01:29

The Colloidal State

The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...

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Controlling Self-Assembly, Ordering, and Stability in Poloxamer/Oil Formulations Using Reverse Poloxamers.

Charles T Knisely1, Grace M Heinecke1, Michael F Coleman1

  • 1Department of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Ave SE, Minneapolis, Minnesota 55455, United States.

Langmuir : the ACS Journal of Surfaces and Colloids
|March 3, 2026
PubMed
Summary
This summary is machine-generated.

Reverse poloxamers (RPs) improve the stability of Poloxamer 407 (P407) and methyl laurate (ML) formulations for drug delivery. The hydrophilic 17R4 RP effectively controls P407 self-assembly and rheology, enhancing formulation properties.

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Poloxamer 407 (P407) is a versatile ABA triblock polymer used in drug delivery, known for temperature-dependent self-assembly.
  • Incorporating additives like methyl laurate (ML) can enhance drug permeation but often compromises formulation stability and mechanical integrity.
  • P407/ML formulations exhibit poor emulsion stability, leading to phase separation, limiting their therapeutic potential.

Purpose of the Study:

  • To investigate the use of reverse poloxamers (RPs), specifically BAB triblock polymers, as additives to stabilize P407/ML formulations.
  • To understand how RPs influence the self-assembly, ordering behavior, and rheological properties of P407/ML systems.
  • To establish a framework for selecting optimal RPs for developing P407-based drug delivery vehicles with tailored properties.

Main Methods:

  • Differential scanning calorimetry (DSC) was employed to analyze thermal transitions.
  • Rheology measurements were used to assess mechanical properties and viscoelastic behavior.
  • Small-angle X-ray scattering (SAXS) was utilized to probe self-assembly structures and ordering.

Main Results:

  • Methyl laurate (ML) induces ordering in P407 at low concentrations by encapsulation within micelles.
  • Addition of RPs (17R2 and 17R4) enhances emulsion stability and increases the maximum modulus of P407/ML formulations.
  • The hydrophilic 17R4 RP significantly alters P407 self-assembly and rheological transitions by delaying ordering through micelle corona interactions.

Conclusions:

  • Reverse poloxamers effectively stabilize P407/ML formulations, improving emulsion stability and mechanical properties.
  • The solubility and incorporation mechanism of RPs dictate their impact on P407 self-assembly and rheology.
  • RPs offer a tunable strategy for controlling the properties of P407 drug delivery systems for specific applications.