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Genetically Simulated GLP-1 Receptor Agonism and Cerebral Small Vessel Disease.

Panagiotis Zangas1, Murad Omarov1, Marios K Georgakis1,2,3

  • 1Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, Germany.

Neurology. Genetics
|March 3, 2026
PubMed
Summary

Genetic variants mimicking Glucagon-like peptide-1 receptor (GLP-1R) agonists were linked to reduced risk of small vessel stroke and white matter hyperintensity. This suggests GLP-1R agonism may offer a new therapeutic avenue for cerebral small vessel disease (cSVD).

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