Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advanced additive manufacturing in orthopedics: a comprehensive review of biomaterials, structural design, biological functions and clinical technology applications.

RSC advances·2026
Same author

Enhanced Elastic Multifunctional Dual-Network Hydrogel Microspheres for the Treatment of Intervertebral Disc Degeneration through Inflammation Modulation and Apoptosis Inhibition.

ACS applied materials & interfaces·2025
Same author

The pB-C2 Serves as an Optimal Evaluation Parameter For The Surgical Management of Patients With Type A Basilar Invagination.

Global spine journal·2025
Same author

Microenvironment Remodeling Microgel Repairs Degenerated Intervertebral Disc via Programmed Delivery of MicroRNA-155.

ACS applied materials & interfaces·2025
Same author

Application of an Injectable Thermosensitive Hydrogel Drug Delivery System for Degenerated Intervertebral Disc Regeneration.

Biomacromolecules·2024
Same author

A Versatile Composite Hydrogel with Spatiotemporal Drug Delivery of Mesoporous ZnO and Recombinant Human Collagen for Diabetic Infected Wound Healing.

Biomacromolecules·2024

Related Experiment Video

Updated: Jun 24, 2026

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
12:22

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

12.5K

A Dual-Strategy Hydrogel Targeting Glycolytic Reprogramming and Inflammation to Inhibit Ferroptosis and Promote

Dengbo Yao1, Yu Tang2, Houqi Chen3

  • 1Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Small (Weinheim an Der Bergstrasse, Germany)
|March 3, 2026
PubMed
Summary

This study developed a novel hydrogel system to treat intervertebral disc degeneration (IVDD). The system reduces inflammation and lactate production, alleviating cell death and promoting tissue repair in IVDD models.

Keywords:
controlled drug releaseenvironment‐responsive hydrogelferroptosisglycolysisintervertebral disc degeneration

More Related Videos

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

12.0K
Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

15.7K

Related Experiment Videos

Last Updated: Jun 24, 2026

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
12:22

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

12.5K
The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

12.0K
Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

15.7K

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Regenerative Medicine

Background:

  • Intervertebral disc degeneration (IVDD) is a significant cause of lower back pain, driven by metabolic shifts like enhanced glycolysis.
  • Lactate accumulation, a product of glycolysis, induces ferroptosis in nucleus pulposus cells (NPCs), worsening IVDD.
  • Inflammation exacerbates glycolysis and lactate production in NPCs, creating a detrimental cycle that accelerates IVDD.

Purpose of the Study:

  • To develop an innovative dual-strategy hydrogel system for treating IVDD.
  • To combine metabolic reprogramming and anti-inflammatory approaches for synergistic therapeutic effects.
  • To investigate the potential of material innovation in modulating metabolic and inflammatory pathways in IVDD.

Main Methods:

  • Encapsulation of lactate dehydrogenase A siRNA (siLDHA) within phenylboronic acid-functionalized G5 PAMAM nanoparticles (GPS).
  • Modification of GPS nanoparticles with epigallocatechin (EGC) to form stable GPS-EGC nanoparticles via borate ester bonds.
  • Incorporation of GPS-EGC nanoparticles into a reactive oxygen species- and pH-responsive hydrogel for controlled release.

Main Results:

  • The dual-strategy hydrogel system effectively reduced IL-1β-induced inflammation and lactate production in NPCs.
  • The system alleviated ferroptosis in NPCs, a key mechanism in IVDD progression.
  • Significant tissue repair was observed in IVDD models treated with the developed hydrogel system.

Conclusions:

  • The developed hydrogel system offers a promising therapeutic strategy for IVDD by targeting both metabolic and inflammatory pathways.
  • Material innovation plays a crucial role in developing advanced treatments for degenerative diseases.
  • This approach demonstrates the potential for synergistic modulation of cellular metabolism and inflammation in regenerative medicine.