DNA-Encoded Libraries (DELs) for Discovering New Molecular Probes: Application to Live-Cell Bioimaging and...

Area of Science:

• Medicinal Chemistry
• Chemical Biology
• Drug Discovery

Background:

• DNA-encoded libraries (DELs) are established tools for small-molecule therapeutics discovery.
• The potential of DELs for developing molecular imaging probes has gained recent recognition.
• Advancements in DEL technology and screening methods enable new probe discovery strategies.

Purpose of the Study:

• To provide an overview of DNA-encoded library technology for molecular probe discovery.
• To highlight recent innovative contributions in DEL-derived probe development.
• To discuss the therapeutic applications of DEL-derived probes, including theranostics.

Main Methods:

• Review of recent literature on DNA-encoded library applications in probe discovery.
• Analysis of emerging screening modalities for DEL campaigns.
• Exploration of strategies for converting DEL-derived probes into therapeutic agents.

Main Results:

• Emergence of robust strategies for generating imaging probes from DEL screening.
• Innovative DEL approaches are significantly advancing molecular probe development.
• DEL-derived probes show promise for therapeutic and theranostic applications.

Conclusions:

• DNA-encoded libraries are a powerful platform for discovering novel molecular imaging probes.
• DEL technology is expanding beyond therapeutics to diagnostics and theranostics.
• Future research will likely focus on integrating DEL-derived probes into clinical applications.