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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more like...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 11, 2013

Infant Infection With Respiratory Syncytial Virus Genotypes and Subsequent Childhood Asthma Risk.

Christian Rosas-Salazar1, Tebeb Gebretsadik2, James D Chappell1

  • 1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

The Journal of Infectious Diseases
|March 3, 2026
PubMed
Summary

Infant respiratory syncytial virus (RSV) infections with specific G gene duplications (Gdups) are linked to a higher risk of childhood asthma. RSV genetic variations may influence asthma development in children.

Keywords:
G geneasthmachildrengenotyperespiratory syncytial virus

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11:48

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Published on: April 4, 2019

Area of Science:

  • Pediatric infectious diseases
  • Respiratory viral infections
  • Asthma epidemiology

Background:

  • Respiratory syncytial virus (RSV) is a common cause of infant respiratory infections.
  • Previous studies suggest a link between RSV infection and childhood asthma.
  • Genetic variations in RSV, such as G gene duplications (Gdups), may influence disease outcomes.

Purpose of the Study:

  • To investigate the association between infant RSV infection with G gene duplications (Gdups) and the risk of developing childhood asthma.
  • To determine if specific RSV genotypes contribute to varying asthma risks.

Main Methods:

  • Prospective, population-based birth cohort study of healthy, term children.
  • Analysis of RSV infection data from infancy.
  • Assessment of childhood asthma at 5 years of age.
  • Statistical analysis using adjusted odds ratios (aOR) and 95% confidence intervals (CI).

Main Results:

  • Infants with RSV-A Gdup+ infections had significantly higher odds of 5-year current asthma (aOR = 2.00, 95%CI = 1.15-3.47).
  • Infants with RSV-B Gdup+ infections also showed increased odds of 5-year current asthma (aOR = 1.78, 95%CI = 1.01-3.11).
  • Children without RSV infection in infancy had lower odds of developing asthma.

Conclusions:

  • RSV infection during infancy, particularly with genotypes containing G gene duplications (Gdups), is associated with an increased risk of childhood asthma.
  • RSV genetic variations contribute to differential risks of childhood asthma.
  • These findings provide evidence for the role of RSV genetic diversity in asthma etiology.