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Correlation between the neutrophil-to-lymphocyte ratio and enlarged perivascular spaces in type 2 diabetes mellitus
Wei Zhang1,2, Zhen Wang1,2, Yaping Sun1,2
1Graduate School of Bengbu Medical University, Bengbu, People's Republic of China.
Aims:
To determine the relationship between the neutrophil-to-lymphocyte ratio and enlarged perivascular spaces in patients with type 2 diabetes mellitus.
Materials And Methods:
Cranial magnetic resonance imaging data from 200 patients with type 2 diabetes mellitus were analyzed to categorize enlarged perivascular spaces in the basal ganglia and centrum semiovale (CSO) by severity. Mild and moderate-to-severe enlarged perivascular spaces groups were compared.
Results:
The neutrophil-to-lymphocyte ratio (NLR) was notably elevated in the moderate-to-severe group compared with the mild group, for both basal ganglia (BG) (P < 0.01) and CSO (P < 0.01) enlarged perivascular spaces. Spearman analyses demonstrated strong positive correlations between the NLR and the severity of both BG (r = 0.545, P < 0.001) and CSO (r = 0.440, P < 0.001) enlarged perivascular spaces. Binary logistic regression analysis identified the NLR as an independent risk factor for BG (P < 0.01) and CSO (P < 0.01) enlarged perivascular spaces in patients with type 2 diabetes mellitus. Receiver operating characteristic curve analysis demonstrated that the NLR had an area under the curve of 0.824 for predicting moderate-to-severe BG enlarged perivascular spaces and 0.768 for predicting moderate-to-severe CSO enlarged perivascular spaces.
Conclusions:
The NLR independently predicts moderate-to-severe BG and CSO enlarged perivascular spaces in patients with type 2 diabetes mellitus and exhibits diagnostic accuracy for cerebral small vessel disease.
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