Related Experiment Video
Updated: Mar 4, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
Published on: May 21, 2013
3D guided large osteochondral allograft reconstructions for post-traumatic osteoarticular bone loss of the knee: a
Nick Assink1,2, Hugo C van der Veen3, Job N Doornberg4,3,5
13D Lab, University of Groningen, University Medical Center Groningen, HPC BB75, Hanzeplein 1, Groningen, 9713 GZ, The Netherlands. n.assink@umcg.nl.
Abstract:
PURPOSE: Post-traumatic osteoarticular bone loss of the knee remains challenging to treat. Allograft reconstruction can yield favourable outcomes, and 3D virtual surgical planning may further improve results by enabling precise templating, optimal graft selection, and accurate fixation. This study aimed to introduce and evaluate 3D-assisted planning for knee allograft reconstruction. METHODS: In two patients with severe post-traumatic knee osteoarticular bone loss—one in the medial distal femur and one in the proximal tibial plateau—3D-assisted resection and allograft reconstruction were performed. An allograft was matched to the affected condyle, after which cutting planes were defined and patient-specific guides were designed. Postoperative CT-scans were obtained to assess accuracy, and patient-reported outcomes were evaluated with the Lower Extremity Functional scale(LEFS) questionnaire. RESULTS: Both surgical procedures went uneventful. In the lateral plateau case, 3D analysis of the postoperative CT scan showed a maximum translational deviation from the plan of 2.2 mm and a maximum rotational deviation of 3.2°. In the medial distal femur case, postoperative 3D assessment revealed a maximum translational deviation of 2.5 mm and a maximum rotational error of 3.5°. Functional outcomes (> 1 year postop) were favourable, with LEFS scores improving from 29/100 to 78/100 in the lateral plateau case and from 22/100 to 81/100 in the medial distal femur case. CONCLUSION: In conclusion, this technical note demonstrates the feasibility and accuracy of 3D-assisted planning for knee allograft reconstruction. The approach enables precise allograft placement and anatomical restoration.
More Related Videos
08:58Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
Published on: May 21, 2013
07:24Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
Published on: January 23, 2018