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Physical Activity Before and During Pregnancy and Neurodevelopment in Early Childhood
Io Kumasaka1, Tomohisa Suzuki1,2, Keita Kanamori1
1Department of Development and Environmental Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Insights
Maternal physical activity before and during pregnancy positively impacts child neurodevelopment, especially motor skills up to one year. More research is needed to understand the underlying physiological mechanisms.
Area of Science:
- Developmental neuroscience
- Maternal and child health
- Exercise physiology
Background:
- Prenatal maternal exercise offers known benefits, yet its specific impact on offspring neurodevelopment requires further investigation.
- Limited research exists on how maternal physical activity influences fetal and child brain development.
Purpose of the Study:
- To examine the association between maternal physical activity levels before and during pregnancy and neurodevelopmental outcomes in children.
- To identify specific developmental domains influenced by maternal exercise during the prenatal period.
Main Methods:
- A nationwide Japanese birth cohort study (Japan Environment and Children's Study) included 38,219 mother-child pairs.
- Maternal physical activity was assessed using the International Physical Activity Questionnaire (IPAQ).
- Child neurodevelopment was evaluated using the Ages and Stages Questionnaires, Third Edition (ASQ-3) from 6 months to 3 years, assessing communication, motor skills, problem-solving, and personal-social domains.
Main Results:
- Higher prepregnancy maternal physical activity was linked to better neurodevelopment across all ASQ-3 domains at 6 months.
- Increased midpregnancy physical activity showed associations with enhanced gross motor, fine motor, and problem-solving skills at 6 months.
- Prepregnancy activity was associated with improved problem-solving skills at 3 years, while midpregnancy activity showed no significant long-term associations with ASQ-3 domains at 3 years.
Conclusions:
- Maternal physical activity before and during pregnancy is associated with improved child neurodevelopment, particularly motor function in early infancy.
- The findings highlight the importance of maternal exercise for child neurodevelopment, especially during the critical early stages.
- Further research is necessary to elucidate the physiological pathways connecting maternal physical activity to neurodevelopmental outcomes in offspring.
Importance:
Prenatal maternal exercise is recognized for its benefits to both mother and child. However, research examining how maternal physical activity influences the neurodevelopment of offspring is limited.
Objective:
To investigate the association between maternal physical activity before and during pregnancy and neurodevelopmental outcomes in children.
Design, Setting, And Participants:
This cohort study analyzed data from the Japan Environment and Children's Study, a nationwide birth cohort funded by the Ministry of the Environment in Japan. Mother-child pairs were recruited and enrolled between January 24, 2011, and March 31, 2014, with child follow-up from birth to 3 years of age. Of 104 062 records, 65 843 were excluded due to missing data or guideline-based criteria, resulting in 38 219 mother-child pairs included in the analysis. The present analysis was conducted between June 24, 2024, and June 30, 2025.
Exposures:
Maternal physical activity levels were assessed before and during pregnancy using the International Physical Activity Questionnaire.
Main Outcomes And Measures:
Child neurodevelopment was assessed using the Ages and Stages Questionnaires, Third Edition, at 6-month intervals from 6 months to 3 years of age. Five developmental domains were evaluated: communication, gross and fine motor skills, problem solving, and personal-social. Scores were based on caregiver responses and compared with established cutoff scores.
Results:
Among the 38 219 mother-child pairs (maternal mean [SD] age, 31.1 [4.8] years; 19 429 [50.8%] male children), multivariable logistic regression showed that higher maternal physical activity was associated with child neurodevelopment. Higher prepregnancy activity was associated with significantly higher odds for each ASQ-3 domain at 6 months of age and higher midpregnancy activity with high odds for the gross motor (odds ratio [OR], 1.18; 95% CI, 1.06-1.33), fine motor (OR, 1.60; 95% CI, 1.37-1.86), and problem solving (OR, 1.23; 95% CI, 1.10-1.38) domains. Higher prepregnancy activity was associated with higher odds for the problem-solving domain (OR, 1.16; 95% CI, 1.01-1.34) at 3 years of age; there was no association with any other domain. Higher midpregnancy activity was not associated with higher odds of any ASQ domain at 3 years of age.
Conclusions And Relevance:
In this cohort study of mother-child pairs, maternal physical activity before and during pregnancy was associated with child neurodevelopment, particularly for motor function between 6 months and 1 year of age. Further investigations are required to find the physiological mechanisms explaining how maternal physical activity affects child neurodevelopment.
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