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Protocol for the establishment of the Pediatric Registry for Stroke as a Multidisciplinary Approach to healthcare
Lucia Gerstl1,2, Victoria Lieftüchter2,3, Eva Jung1,4
1Division of Pediatric Neurology and Developmental Medicine, Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University (LMU) Hospital, LMU Munich, Munich, Germany.
Insights
The Pediatric Registry for Stroke as a Multidisciplinary Approach to healthcare research (PRiSMA) is a new study collecting data on childhood stroke. This research aims to improve diagnosis, treatment, and long-term care for pediatric stroke patients.
Area of Science:
- Pediatric Neurology
- Clinical Research
- Stroke Medicine
Background:
- Childhood stroke is rare but serious, requiring specialized care and long-term management.
- Current management often lacks high-quality evidence, relying on expert opinion and retrospective data.
- Pediatric stroke presents unique challenges compared to adult stroke.
Purpose of the Study:
- To systematically collect longitudinal, prospective data on childhood stroke (PRiSMA study).
- To optimize diagnosis, personalized acute therapy, neurorehabilitation, and recurrent stroke prevention.
- To inform future hypothesis-driven studies and facilitate clinical collaboration.
Main Methods:
- Recruiting children and adolescents (≥28 days to 18 years) with arterial ischemic stroke (AIS) or hemorrhagic stroke (HS).
- Nationwide, multicenter data collection in acute and chronic phases from medical records and caregiver history.
- Collecting quality of life and behavioral data via questionnaires; international collaboration across Germany, Austria, and the Netherlands.
Main Results:
- 16 centers in Germany and 1 in Austria are actively recruiting.
- Currently, 30 patients with AIS and 1 with HS are enrolled (as of November 17, 2025).
Conclusions:
- The PRiSMA registry is actively collecting crucial data on pediatric stroke.
- This prospective data will enhance understanding and management of childhood stroke.
- The registry facilitates collaboration and future research in pediatric stroke.
Background:
Childhood stroke is a rare but potentially life-threatening event that can occur at any age. It requires prompt diagnosis and appropriate treatment, and, in view of the frequent neurological and neurocognitive sequelae, long-term care in a multidisciplinary and multiprofessional setting. The management of stroke in children, which differs in many aspects from stroke in adults, often relies on local expert opinions and retrospectively collected data rather than high-quality evidence from prospective randomized controlled clinical trials, especially in the acute phase.
Aims:
The Pediatric Registry for Stroke as a Multidisciplinary Approach to healthcare research (PRiSMA) study aims to systematically collect longitudinal prospective observational data across the acute and long-term phases to optimise diagnosis, personalised acute therapy, neurorehabilitation, and prevention of recurrent stroke. The data will inform development of further hypothesis-driven studies of childhood stroke in national and international networks. Furthermore, PRiSMA will facilitate case-specific collaboration within the registry network, allowing treating clinicians to consult experienced colleagues on complex cases.
Methods:
In PRiSMA all children and adolescents (>28 days of life, ≤ 18years) with arterial ischemic stroke (AIS) or hemorrhagic stroke (HS) are eligible for recruitment. The nationwide multicenter, systematic data collection is performed in the acute and chronic phases, extracted from patient medical records supplemented by direct registry-specific medical history provided by caregivers. In addition, a questionnaire-based data on quality of life and behaviour will be collected. International collaborations are established across Germany, Austria and the Netherlands.
Status:
Currently, 16 centres in Germany and 1 centre in Austria have commenced recruitment. 30 patients are currently (17 Nov 25) enrolled after arterial ischaemic stroke and 1 after haemorrhagic stroke.
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