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Development and Human Extrapolation of Physiologically Based Toxicokinetic Models for Chlorinated Polyfluoroalkyl

Jing Zhang1,2, Huihui Bao2, Wen-Hui Zhao1

  • 1Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.

Environmental Science & Technology
|March 3, 2026
PubMed
Summary

Physiologically based toxicokinetic (PBTK) models for chlorinated polyfluoroalkyl ether sulfonates (F-53B) were developed in rats and extrapolated to humans. These models improve risk assessment for F-53B exposure in the general adult population.

Keywords:
6:2 Cl-PFESA8:2 Cl-PFESAF-53Bhealth risk assessmentphysiologically based toxicokinetic (PBTK) modeling

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