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HARMONIC organ dose calculation framework for cardiac fluoroscopy.

Jérémie Dabin1, Mahmoud Abdelrahman1, David Borrego2

  • 1Belgian Nuclear Research Center (SCK CEN), Mol, Belgium.

Biomedical Physics & Engineering Express
|March 3, 2026
PubMed
Summary
This summary is machine-generated.

A new software tool, HARMONIC-CardioDose, provides rapid and accurate organ dose estimates for pediatric and adult patients undergoing cardiac fluoroscopy. This tool supports radiation protection and cancer risk assessment in children.

Keywords:
HARMONICMonte Carlo simulationcardiac fluoroscopyradiation doses

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Area of Science:

  • Medical physics
  • Pediatric radiology
  • Radiation dosimetry

Background:

  • Cardiac fluoroscopy procedures expose children to ionizing radiation, necessitating accurate dose estimation for cancer risk assessment.
  • The HARMONIC study investigates the health effects of cardiac fluoroscopy in pediatric patients.
  • Estimating organ doses for a large patient cohort is crucial for understanding radiation-induced cancer incidence.

Purpose of the Study:

  • To develop and validate a software tool for rapid and accurate estimation of organ doses in pediatric and adult patients undergoing cardiac fluoroscopy.
  • To support the HARMONIC study's objective of investigating the relationship between ionizing radiation and cancer incidence in children.
  • To provide a freely available tool for patient dosimetry in interventional cardiology.

Main Methods:

  • Organ doses were calculated using the MCNP6.2 Monte Carlo code with eight anthropomorphic phantoms representing various pediatric and adult age groups.
  • Simulations covered a wide range of technical parameters, including beam angles, filtration, tube voltages, and field sizes.
  • Calculated organ doses were normalized to the air kerma-area product (PKA) to derive PKA-to-organ-dose conversion coefficients, extended via interpolation.

Main Results:

  • PKA-to-organ-dose conversion coefficients were computed for 22,176 exposure configurations and interpolated to over 2.6 million.
  • The HARMONIC-CardioDose software tool was developed, embedding coefficients for 15 key organs.
  • The software enables rapid estimation of organ doses for diverse exposure scenarios within the simulation range.

Conclusions:

  • HARMONIC-CardioDose is a validated software tool for estimating organ doses in pediatric and adult patients undergoing interventional cardiology procedures.
  • The tool facilitates accurate patient dosimetry, crucial for radiation protection and epidemiological studies like HARMONIC.
  • The software is freely available to the medical and research community, promoting advancements in pediatric radiation safety.