Analysis of the application value of multi-slice spiral CT and multimodal MRI in screening patients with bipolar...

BIPOLAR: disorder (BD) is a complex psychiatric condition. Multi-slice spiral computed tomography (MSCT) and multimodal magnetic resonance imaging (MRI), offer potential tools for improving diagnostic accuracy.

To evaluate application value of multi-slice spiral CT and multimodal MRI in screening patients with BD.

The study included 150 participants (75 BD patients and 75 age- and sex-matched healthy controls). Participants underwent comprehensive psychiatric evaluation, MSCT scanning, and multimodal MRI including structural, functional, and diffusion tensor imaging.

MSCT revealed significant reductions in gray matter volume in prefrontal cortex (350±45 vs. 385±50 cm³, p < 0.001), anterior cingulate cortex (120±15 vs. 135±18 cm³, p = 0.002), and temporal lobes (250±30 vs. 280±35 cm³, p < 0.001) in BD patients. Multimodal MRI demonstrated decreased functional connectivity within the default mode network (correlation coefficient: 0.45±0.10 vs. 0.60±0.08, p < 0.001) and reduced fractional anisotropy in white matter tracts. Combined MSCT and multimodal MRI showed superior diagnostic performance (sensitivity 92 %, specificity 90 %, AUC 0.95) compared to individual modalities (MSCT: AUC 0.80; MRI: AUC 0.90). Imaging findings significantly correlated with clinical measures, including YMRS scores (r=-0.42, p < 0.001) and GAF scores (r = 0.35, p = 0.003).

Combined application of MSCT and multimodal MRI significantly enhances diagnostic accuracy for bipolar disorder compared to either modality alone.