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Related Experiment Video

Updated: May 12, 2026

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
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Published on: November 20, 2015

Comparing Susceptibility-Weighted Imaging and T2* Gradient-Recalled Echo for Cerebral Microbleeds Detection: A

Su Jeong Yang1, Jae-Sung Lim2, Yangsean Choi3

  • 1Department of Radiology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.

Journal of Clinical Neurology (Seoul, Korea)
|March 3, 2026
PubMed
Summary

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Susceptibility-weighted imaging (SWI) detects cerebral microbleeds 1.6 times more effectively than gradient-recalled echo (GRE). This finding is crucial for refining diagnostic criteria in anti-amyloid therapies.

Area of Science:

  • Neuroimaging
  • Radiology
  • Clinical Trials

Background:

  • Amyloid-related imaging abnormalities criteria in anti-amyloid therapy rely on T2* gradient-recalled echo (GRE).
  • Susceptibility-weighted imaging (SWI) is commonly used, creating diagnostic uncertainty.
  • Quantitative comparison of SWI and GRE for cerebral microbleed detection is needed.

Purpose of the Study:

  • To quantitatively compare the detectability of SWI and GRE for cerebral microbleeds.
  • To establish evidence supporting distinct microbleed criteria for SWI and GRE.
  • To address uncertainty in anti-amyloid therapy monitoring due to differing imaging techniques.

Main Methods:

  • Systematic review and meta-analysis following PRISMA guidelines.
  • Searched PubMed and Embase for studies comparing SWI and GRE.
Keywords:
T2* gradient-recalled echoamyloid-related imaging abnormalitiesanti-amyloid therapycerebral microbleedsusceptibility-weighted imaging

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  • Calculated pooled proportion of microbleed detection and detection ratio, with subgroup analyses for field strength and slice thickness.

    • Main Results:

    • SWI detected cerebral microbleeds approximately 1.6 times more effectively than GRE.
    • SWI showed higher detectability at both 3.0 T (1.7-fold) and 1.5 T (1.5-fold).
    • Thinner SWI slices (<2 mm) improved detection by 1.9-fold compared to 1.3-fold for thicker slices (≥2 mm).

    Conclusions:

    • SWI demonstrates significantly higher sensitivity for detecting cerebral microbleeds than GRE.
    • Differences between SWI and GRE necessitate cautious exploration of adjusted diagnostic thresholds.
    • Prospective validation in therapy-specific cohorts is essential for clinical application of adjusted criteria.