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Updated: Jun 21, 2026

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

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Published on: April 3, 2015

Mineralization-driven cellular dynamics and tissue remodeling in scaffold-free MC3T3-E1 spheroids

Jeonghyun Kim1, Ryotaro Ikebe2, Eijiro Maeda2

  • 1Department of Mechanical Systems Engineering, Graduate School of Engineering, Nagoya University, Furou-cho, Chikusa-ku, Nagoya 464-8603, Japan; Division of Bioengineering, Department of Mechanical Engineering, Graduate School of Engineering, Kyushu University, Fukuoka 819-0395, Japan.

Journal of Bioscience and Bioengineering
|March 3, 2026
PubMed
Summary

This study reveals that bone mineralization begins in the core of 3D cell cultures, leading to increased stiffness. This process is crucial for understanding bone formation in tissue engineering and regenerative medicine.

Keywords:
BoneCollagenCompression testMC3T3-E1Mechanical propertyMineralizationNucleusSpheroidYoung's modulus

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